As you’ll begin to see, there’s so much to understand about how the CBS gene upregulations can potentially effect your health, especially if you have a neuro-immune illness, chronic fatigue, fibromyalgia, chemical sensitivity, cardiovascular problems, Autism, or another disorder that may be impacted by methylation.
It can be difficult to keep it all straight. So I’ve outlined some of the key points from my reading to make it easier for myself and hopefully for you too.
The genes involved are:
- CBS C699T
- CBS A360A
- CBS N212N
The impact can vary dramatically depending on whether you have a single copy or double copy of the gene and which gene is expressed. For example, the impact of C699T is said to be much stronger than that of CBS A360A.
Following are my key points, which I plan to add to from time to time. When I do, I’ll add a note at the beginning of the article indicating it’s been updated.
CBS Upregulations – when expressed – may lead to:
- Increased taurine and decreased gluthathione, the latter being one of the most important antioxidants in the body. This can also lead to lower levels of homocysteine, cysteine and cysthione.
- Excess ammonia, which wastes BH4. This can lead to mast cell granulation and increase histamine levels. BH4 is needed to make dopamine, serotonin, and nitric oxide so there are additional knock-on effects when these neurotransmitters are low.
- Increased alpha-keoglutamate leading to excitotoxicity, which can cause nerve damage.
- Increase hydrogen sulfide, which can lead to brain fog.
- Excess sulfur breakdown products: sulfites and sulfates. Excess sulfites can be toxic. Excess sulfates can stimulate the stress/cortisol response also knows as the “flight or fight” response.
- The G6PHD enzyme system may be affected leading to abormalities in sugar control.
I found all of this to be very illuminating in relation to my own health, explaining what had been a mystery for many years.
To understand the full picture, please read:
- Chapter 6 of Dr. Amy Yasko’s free book, Autism Pathways to Recovery – You can download this 300+ page book for free on her home page where it says Free Articles.
- This section on on the Heartfixer blog, specifically on the potential impacts of CBS upregulatons.
Remember, I’m not a doctor. Please discuss these issues with your healthcare provider before taking any specific steps.
I would love to hear any thoughts you have on the topic. Please share in the comments. Warmly, Sandra
Mast Cells and Me 